Multi-scale, tailor-made heart simulation can predict the effect of cardiac resynchronization therapy

Cardiac Simulation to Personalize Cardiac Resynchronization Therapy.

Can cardiac resynchronization therapy cause harm?

Most beneficial and effective therapies also have the potential to cause harm. Cardiac resynchronization therapy (CRT) is now proven by large-scale clinical trials to be highly beneficial for chronic heart failure patients, with reduction in mortality and re-hospitalization, and improved quality of life. However, it does have potential adverse effects such as those associated with any pacemaker...

Cardiac Resynchronization Therapy for Heart Failure

In the current issue of Circulation, Anand and colleagues representing the COMPANION (The Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure) Investigators have brought forward compelling data that emphasize the substantial morbidity benefit of cardiac resynchronization therapy (CRT) in patients with moderately severe to severe heart failure. Unlike other studies that hav...

Cardiac Resynchronization Therapy for Heart Failure

The weight of evidence supporting the routine use of cardiac resynchronization therapy, or atrial-synchronized biventricular pacing, as a treatment for patients with moderate-to-severe chronic systolic heart failure and ventricular dyssynchrony is now quite substantial. Results from mechanistic studies, observational evaluations, and randomized, controlled trials have consistently demonstrated ...

Cardiac resynchronization therapy for mild heart failure.

It has been firmly established that cardiac resynchronization therapy (CRT) reduces symptoms and improves mortality in patients with moderate-to-severe chronic heart failure [New York Heart Association (NYHA) class III-IV], despite optimal heart failure medication and with wide QRS complex on the surface electrocardiogram as evidence of ventricular dyssynchrony, but not whether such treatment i...